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Pharmacokinetic & Pharmacodynamic Studies
vivoPharm has substantial experience in the conduct of pharmacokinetic and pharmacodynamic studies in preclinical models with anti-cancer agents as well as other drugs.
Our pharmacokinetic (PK) assays are designed to assess the action of your compounds over a period of time, focusing particularly on absorption, distribution, localisation in tissues, biotransformation and excretion. vivoPharm's pharmacodynamic (PD) studies deal with the biochemical and physiological effects of your compounds and the mechanisms of their actions.
Some of our past studies have involved:
Bioavailability studies
Liquid Chromatography-Mass Spectrometry/Mass Spectrometry
Fate of drugs in vivo
Metabolism studies in the liver
P450 enzyme studies
In addition, vivoPharm offers a suite of in vivo and in vitro tests and will happily tailor assays to your PK/PD needs.
All of vivoPharm's studies can be conducted in accordance with Good Laboratory Practice (GLP), Federal Drug Administration (FDA) or other industrial and/or regulatory standards as required.
in vivo Services
vivoPharm provides bioanalytical support for samples generated in toxicology studies and the resulting data can be interpreted by our pharmacokinetics staff using industrial standards. Both non-compartmental and compartmental approaches are available. We offer this as part of our signature integrated service, some components of which are done in collaboration with our partner Tetra Q.
Toxicokinetic parameter estimation output includes a comprehensive, professionally prepared report of the data. In addition, we can address preclinical to clinical considerations. For example, we offer allometric scaling, which is crucial when planning first-time-in-man (FTIM) studies.
vivoPharm's suite of in vivo PK/PD services include:
Non-compartmental pharmacokinetics
Compartmental pharmacokinetics and simulations
Ascending dose or assessment of dose proportionality
Repeat dose of assessment of multiple dose linearity
Bioavailability and bioequivalence
Drug interaction studies
Special populations
Pharmacodynamic and pharmacokinetic modeling
Deconvolution
in vitro Services
vivoPharm's in vitro department offers services to assist our clients in completing the metabolic, toxicokinetic and bioanalytical investigations undertaken in pharmaceutical product development. Our in vitro specialists provide qualitative and quantitative data to address a variety of regulatory questions. in vitro studies can be conducted with both radiolabelled and non-radolabelled test articles as required.
In addition, we offer in vitro PK/PD services including:
Cell viability and cytotoxicity
Enzyme and immunoassays, such as ELISA, RIA, DPP-IV
Cell proliferation